Initially I would say no, but it depends how it's implemented. For example if you had to watch an ad before you started reading anything and weren't bothered until the next time you opened the book then it might be ok.
Chances are the ads would be strategically placed as to interrupt and destroy the climax of the story to force you through the ad because you want to see what's next. It's all about anticipation. For that reason, I'd say no.
-HD